International Health Care
Liver V cod. 905066484 list. €27,00
Pure extract of Andrographis paniculata (title
98% Andrographolide )
Schizandra chinensis extract (title 9%
Myrica cerifera extract (title 50%
SERVING THREE TABLETS):
Andrographolide 730 mg
Schizandrin 54 mg
Dihydromyricetin 150 mg
Andrographis paniculata (Acanthaceae)
(AP), also known commonly as "King of Bitters," is a member of the
plant family Acanthaceae, and has been used for
centuries in Asia to treat GI tract and upper
respiratory infections, fever, herpes1, viruses2, 3
and a variety of other chronic and infectious diseases.
It is found in the Indian Pharmacopoeia and is
the prominent in at least 26 Ayurvedic formulas;
whereas in Traditional Chinese Medicine (TCM),
Andrographis is an important "cold property" herb:
it is used to rid the body of heat, as in fevers,
and to dispel toxins from the body.
In Scandinavian countries, it is commonly used to prevent
and treat common colds. Research conducted in the '80's
and '90's has confirmed that Andrographis, properly
administered, has a surprisingly broad range of
pharmacological effects, some of them extremely beneficial:
-1)Antiviral properties of
ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of
herpes simplex virus type 1.Wiart C, Kumar K, Yusof MY, Hamimah H, Fauzi
ZM, Sulaiman M. Department of Pharmacy, Faculty of Medicine, University
of Malaya, Malaysia.
phase I trial of andrographolide in HIV positive patients and normal
Calabrese C, Berman SH, Babish JG, Ma
X, Shinto L, Dorr M, Wells K, Wenner CA, Standish LJ.
Bastyr University Research Institute, Bastyr University, Washington
98028, USA. firstname.lastname@example.org
A phase I dose-escalating clinical trial of andrographolide from
Andrographis paniculata was conducted in 13 HIV positive patients and
five HIV uninfected, healthy volunteers. The objectives were primarily
to assess safety and tolerability and secondarily to assess effects on
plasma virion HIV-1 RNA levels and CD4(+) lymphocyte levels. No subjects
used antiretroviral medications during the trial. Those with liver or
renal abnormalities were excluded. The planned regimen was 5 mg/kg
bodyweight for 3 weeks, escalating to 10 mg/kg bodyweight for 3 weeks,
and to 20 mg/kg bodyweight for a final 3 weeks. The trial was
interrupted at 6 weeks due to adverse events including an anaphylactic
reaction in one patient. All adverse events had resolved by the end of
observation. A significant rise in the mean CD4(+) lymphocyte level of
HIV subjects occurred after administration of 10 mg/kg andrographolide
(from a baseline of 405 cells/mm(3) to 501 cells/mm(3); p = 0.002).
There were no statistically significant changes in mean plasma HIV-1 RNA
levels throughout the trial. Andrographolide may inhibit HIV-induced
cell cycle dysregulation, leading to a rise in CD4(+) lymphocyte levels
in HIV-1 infected individuals. Copyright 2000 John Wiley & Sons, Ltd.
PMID: 10925397 [PubMed - indexed for MEDLINE]
bis-andrographolide ether from Andrographis paniculata nees and
evaluation of anti-HIV activity.Reddy VL, Reddy SM, Ravikanth V,
Krishnaiah P, Goud TV, Rao TP, Ram TS, Gonnade RG, Bhadbhade M,
Venkateswarlu Y. Natural Products Laboratory, Organic Chemistry
Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007,
Schisandra contains a number of compounds, including essential oils,
numerous acids, and lignans. Lignans (schizandrin, deoxyschizandrin,
gomisins, and pregomisin) are found in the seeds of the fruit and have a
number of medicinal actions.
The classical treatise on Chinese herbal medicine, the Shen Nung Pen
Tsao Ching, described schisandra as a high-grade herbal drug useful for
a wide variety of medical conditions—especially as a kidney tonic and
lung astringent. Chinese herbalists use schisandra for coughs, night
sweats, insomnia, thirst, and physical exhaustion.
Useful for the treatment of:
• chemotherapy support
• common cold/sore throat
• liver support
Modern Chinese research suggests that lignans in schisandra regenerate
liver tissue damaged by harmful influences such as viral hepatitis and
alcohol. Lignans lower blood levels of serum glutamic pyruvic
transaminase (SGPT), a marker for infective hepatitis and other liver
Schisandra fruit may also have an adaptogenic action, much like the herb
ginseng, but with weaker effects. Laboratory work suggests that
schisandra may improve work performance, build strength, and help to
Schisandra is a woody vine with numerous clusters of tiny, bright red
berries. It is found throughout northern and northeast China and the
adjacent regions of Russia and Korea. The fully ripe, sun-dried fruit is
used medicinally. It has sour, sweet, salty, hot, and bitter tastes.
This unusual combination of flavors is reflected in schisandra’s Chinese
name wu-wei-zi, meaning “five taste fruit.”
also called Ampelopsin ; is a naturally occurring
flavonoid that is found in berries, fruit, vegetables, herbs, tea, and
small molecule inhibitor of HIV-1 4
Research has shown that
myricetin has antioxidant5,6 and
anti-inflammatory properties. It may also help lower cholesterol.
Myricetin is found in bark,
leaves, and roots of the plant myrica cerifera. It is completely soluble
in water which is why is it popluar for tea.
-4): Biomed Environ Sci. 2004
Ampelopsin, a small molecule inhibitor of HIV-1 infection targeting
HIV entry.Liu DY, Ye JT, Yang WH, Yan J, Zeng CH, Zeng S.
Department of Chemistry, Zhongshan Medical College, Sun Yat-sen
University, Guangzhou 510089, Guangdong, China. email@example.com
OBJECTIVE: To investigate the anti-HIV effects of ampelopsin and its
interaction with HIV-1 coreceptor CXCR4. METHODS: Through anti-virus
experiments in vitro, the inhibitory effect of ampelopsin on HIV-1
infection was verified. Chemotaxis assay was performed to show the
ability to induce PBMCs migration by ampelopsin, RANTES and SDF-1alpha.
Fluorescence labelling monoclonal antibody was utilized to observe the
interaction of ampelopsin and CXCR4. Mice immunosuppressant model was
also established to detail the role ampelopsin played in regulating
cellular immunological functions. RESULTS: Ampelopsin could protect
sensitive cells against HIV-1 infection and dramatically reduce HIV-1
antigen P24 expression. HIV-1SF33 attaching to MT-4 cells was interfered
by ampelopsin, and the EC50 was 0.175 mg/mL for cellular protection and
0.024 mg/mL for P24 inhibition. At co-cultivating phase, EC50 was 0.229
mg/mL and 0.197 mg/mL respectively. Furthermore, the EC50 was 0.179
mg/mL and 0.348 mg/mL in acute infection. Human PBMCs migration was
induced after being challenged with ampelopsin or chemokines, and
synergistic action was observed during co-treatment. Ampelopsin alone
resulted in maximal chemotaxis at 1 mg/mL. HIV-1 co-receptor CXCR4 on
the surface of PBMCs was decreased by internalization, which indicated
the effect of ampelopsin on CXCR4. About 70% CXCR4 was reduced by
ampelopsin at 1 mg/mL. Ampelopsin also augmented cellular immunological
functions in immunosuppressive mice. CONCLUSION: Ampelopsin displays a
strong inhibitive role during HIV-1 absorption, incubation and acute
infection. These results are coincident with its immune enhancement.
PMID: 15386941 [PubMed - indexed for MEDLINE]
-5) Biofactors. 2004;21(1-4):175-8.
Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis
grossedentata, and ampelopsin.Murakami T, Miyakoshi M, Araho D, Mizutani
K, Kambara T, Ikeda T, Chou WH, Inukai M, Takenaka A, Igarashi K.
Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089-8, Sagata,
Shin-ichi, Fukuyama-city, Hiroshima 729-3102, Japan.
Hepatoprotective effect of the leaves and stems of Ampelopsis
grossedentata together with its main constituent, ampelopsin, were
examined on D-galactosamine induced liver injury in rats. The diet
containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly
suppressed the increase of LDH, ALT, AST, alpha-tocopherol levels and
GSG/GSSH caused by GalN treatment. These results suggested that
ampelopsin from Tocha acted to prevent the oxidative stress in vivo that
may have been due to active oxygen species formed by a macrophage by the
action of GalN.
PMID: 15630194 [PubMed - indexed for MEDLINE]
-6)Zhongguo Zhong Yao Za Zhi. 2003
[Studies on the effect of dihydromyricetin on
antilipid-peroxidation][Article in Chinese]
He GX, Yang WL, Pei G, Zhu YH, Du FL.
College of Food Science and Technology, Hunan Agricultural Univeisity,
Changsha 410128, Hunan, China. firstname.lastname@example.org
OBJECTIVE: To study the effects of Dihydromyricetin (DMY) on
antilipid-peroxidation. METHOD: The antilipid-peroxidation of DMY on
heart, liver, brain tissue homogenate and mitochondria was measured by
the determination of malondiadehyde (MDA) induced by Fe2+ -Vit C, Fe2+
-H2O2, Fe-Cys with TBA spectrometric method. RESULT: DMY could inhibit
the lipid peroxidation of homogenate and mitochondria. The inhibition
exhibited concentration-dependent manner. CONCLUSION: DMY has good
antilipid-peroxidation effect, which is worth studing further.
PMID: 15617509 [PubMed - indexed for MEDLINE]